Best 50 Alternative 3′ Cleavage Sites Result In:

Alternative 3′ Cleavage Sites Result In:

What is the significance of multiple 3’ cleavage sites?

(b) With multiple 3′ cleavage sites, there are two or more potential sites for cleavage and polyadenylation; use of the different sites produces mRNAs of different lengths. * * Figure 14.16 Mature eukaryotic mRNA is produced when pre-mRNA is transcribed and undergoes several types of processing.

What is polyadenylation and alternative cleavage?

Alternative cleavage and polyadenylation: extent, regulation and function The 3' end of most protein-coding genes and long non-coding RNAs is cleaved and polyadenylated. Recent discoveries have revealed that a large proportion of these genes contains more than one polyadenylation site.

What is global cleavage enhancement at proximal poly (A) sites?

Global enhancement of cleavage at proximal poly (A) sites was also detected in conditions of cardiac hypertrophy, which is an enlargement of the heart that occurs in response to physiological or pathological stimuli 65. Uncontrolled cellular proliferation is a hallmark of cancer development.

Is cleavage Factor Im a heterotetrameric protein complex?

Kim, S. et al. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells 15, 1003–1013 (2010).

Alternative 3′ Cleavage Sites Result In:

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